ZURICH – Laboratory of Neuro-epigenetics, University and ETH Zurich


How Is Childhood Trauma Transmitted Across Generations?

Isabelle Mansuy and her PLEX Research Partners discuss a number of topics from grant applications to epi-genetics and trauma, visting some old cliches on the way…

ZURICH - Laboratory of Neuro-epigenetics, University and ETH Zurich

Latest Episode

  • Synergies - ETH Zurich

    Meeting 02 Episode 07 – Why use mice for these experiments?

    Epigenetics or just plain old genetic variability? Tracking changes in DNA means you need to start with a level playing field and Isabelle explains why mice are the model subject... +

  • Synergies - ETH Zurich

    Meeting 1 Episode 1 – From Purgatory to Paradise

    Cutting edge research needs money - Isabelle and her PLEX Research Partners discuss the often fruitless task of finding the funds… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 2 – There Really is a Biological Basis…

    On the track of trauma - and Renaud begins to feel the impact of SYNERGIES… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 3 – De-mystification

    Isabelle dispels rumours of a “double life” which leads to an exchange around a haunting professional dilemma… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 4 – Useful and Constructive

    Isabelle reveals the advantages participating in SYNERGIES and Cecilia evokes the problems she has with taking her medication… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 5 – Some Epigenetic Markers

    The meeting begins to get “technical” as Isabelle and Renaud discuss the markers and mechanisms involved in Transgenerational Epigenetic Inheritance (TEI)… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 6 – Another Epigenetic Mechanism

    The ZURICH team continue their discussion around DNA and microRNA methylation and touch on the reasons why it is so difficult to treat psychiatric disorders… +

  • Synergies - ETH Zurich

    Meeting 1 Episode 7 – The Limbic System

    Renaud outlines his theory of the origins of empathy - much to the amusement of the others in the room… +

Research Partners

Hasna – PLEX RP

Cecilia – PLEX RP

Renaud – PLEX RP

Isabelle – PI

In this second series of videos, Isabelle Mansuy and her PLEX Research Partners, Cecilia, Hasna and Renaud try to draw a circle around the roots and definitions of trauma… 

  • Synergies - ETH Zurich

    Meeting 2 Episode 1 – What is trauma?

    Isabelle digs deep in an effort to explain what trauma means to her, with a little help from her PLEX Research Partners of course… +

  • Synergies - ETH Zurich

    Meeting 2 Episode 2 – Humiliation – I never thought it could be so destructive…

    What shape can trauma take? Isabelle Mansuy’s group touch upon the impact of childhood humiliation... +

  • Synergies - ETH Zurich

    Meeting 2 Episode 3 – The impact of SYNERGIES

    Isabelle Mansuy begins a discussion around how SYNERGIES has altered her world view and what this implies for the future of her research... +

  • Synergies - ETH Zurich

    Meeting 2 Episode 4 – Why me?

    Cecile attempts to address the injustice of mental illness when she asks "why me?" +

  • Synergies - ETH Zurich

    Meeting 2 Episode 5 – Does This Make You Angry?

    Cecilia and Renaud reveal how they deal with anger and how acceptance rather than forgiveness is the more likely the solution... +

  • Synergies - ETH Zurich

    Meeting 2 Episode 6 – The Physical Legacy of Trauma

    Trauma - never mind the mind, trauma leaves scars everywhere in the body... +

  • Synergies - ETH Zurich

    Meeting 02 Episode 07 – Why use mice for these experiments?

    Epigenetics or just plain old genetic variability? Tracking changes in DNA means you need to start with a level playing field and Isabelle explains why mice are the model subject... +

Research Partners

Hasna – PLEX RP

Cecilia – PLEX RP

Renaud – PLEX RP

Isabelle – PI

  • Synergies – ETH Zurich

    Meeting 03 Episode 01 – What do we mean by “trauma”? – A second look…

    What do we mean when we talk about “trauma”? Isabelle and her PLEX-RPs take another shot at defining the phenomenon at the heart of her research - without which, a deeper understanding of the scientific and clinical ramifications are difficult +

  • Synergies – ETH Zurich

    Meeting 03 Episode 02 – How do we deal with the mental fallout of trauma?

    What happens once you realise you have suffered severe childhood trauma? Cecilia reveals a bilateral approach to being bipolar... +

Research Partners

Hasna – PLEX RP

Cecilia – PLEX RP

Renaud – PLEX RP

Isabelle – PI

  • COVID CONFABS

    COVID CONFABS – E01

    Isabelle Mansuy shares her own "lockdown routine" during the first month of the COVID-19 pandemic... +

  • COVID CONFABS

    COVID CONFABS – E02

    Jacqueline looks back 10 years and compares the current pandemic with her mental state then +

  • COVID CONFABS

    COVID CONFABS – E03

    Isabelle explains how being in lockdown led her team to a new scientific discovery... +

  • COVID CONFABS

    COVID CONFABS – E04

    Isabelle introduces the “Early Cause” consortium while experiments carried out during lockdown find a link between cardiovascular disease and trans-generational trauma... +

  • COVID CONFABS

    COVID CONFABS – E05

    When things go wrong in childhood, it isn’t just the child who suffers. Isabelle offers some hope and scientific evidence of how this deeply disturbing reality might be avoided... +

  • COVID CONFABS

    COVID CONFABS – E06

    How does childhood trauma launch us towards psychiatric issues later in life? Laurence alludes to her own experience and fingers “hypersensitivity” as the culprit... +

MORE PROJECTS

University Hospital of Psychiatry and Psychotherapy
Laboratory for Investigative Neurophysiology, CHUV
Perron Institute and UWA Medical School