Isabelle Mansuy and her PLEX Research Partners discuss a number of topics from grant applications to epi-genetics and trauma, visting some old cliches on the way…
ZURICH - Laboratory of Neuro-epigenetics, University and ETH Zurich
Latest Episode
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Meeting 04 Episode 06 – Living with mental illness is a full-time job…
Isabelle listens carefully as the PLEX-RPs build a picture of mental illness that steals your existence and is all consuming... +
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Meeting 1 Episode 1 – From Purgatory to Paradise
Cutting edge research needs money - Isabelle and her PLEX Research Partners discuss the often fruitless task of finding the funds… +
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Meeting 1 Episode 2 – There Really is a Biological Basis…
On the track of trauma - and Renaud begins to feel the impact of SYNERGIES… +
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Meeting 1 Episode 3 – De-mystification
Isabelle dispels rumours of a “double life” which leads to an exchange around a haunting professional dilemma… +
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Meeting 1 Episode 4 – Useful and Constructive
Isabelle reveals the advantages participating in SYNERGIES and Cecilia evokes the problems she has with taking her medication… +
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Meeting 1 Episode 5 – Some Epigenetic Markers
The meeting begins to get “technical” as Isabelle and Renaud discuss the markers and mechanisms involved in Transgenerational Epigenetic Inheritance (TEI)… +
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Meeting 1 Episode 6 – Another Epigenetic Mechanism
The ZURICH team continue their discussion around DNA and microRNA methylation and touch on the reasons why it is so difficult to treat psychiatric disorders… +
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Meeting 1 Episode 7 – The Limbic System
Renaud outlines his theory of the origins of empathy - much to the amusement of the others in the room… +
Research Partners
Hasna – PLEX RP
Cecilia – PLEX RP
Renaud – PLEX RP
Isabelle – PI
In this second series of videos, Isabelle Mansuy and her PLEX Research Partners, Cecilia, Hasna and Renaud try to draw a circle around the roots and definitions of trauma…
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Meeting 2 Episode 1 – What is trauma?
Isabelle digs deep in an effort to explain what trauma means to her, with a little help from her PLEX Research Partners of course… +
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Meeting 2 Episode 2 – Humiliation – I never thought it could be so destructive…
What shape can trauma take? Isabelle Mansuy’s group touch upon the impact of childhood humiliation... +
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Meeting 2 Episode 3 – The impact of SYNERGIES
Isabelle Mansuy begins a discussion around how SYNERGIES has altered her world view and what this implies for the future of her research... +
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Meeting 2 Episode 4 – Why me?
Cecile attempts to address the injustice of mental illness when she asks "why me?" +
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Meeting 2 Episode 5 – Does This Make You Angry?
Cecilia and Renaud reveal how they deal with anger and how acceptance rather than forgiveness is the more likely the solution... +
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Meeting 2 Episode 6 – The Physical Legacy of Trauma
Trauma - never mind the mind, trauma leaves scars everywhere in the body... +
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Meeting 02 Episode 07 – Why use mice for these experiments?
Epigenetics or just plain old genetic variability? Tracking changes in DNA means you need to start with a level playing field and Isabelle explains why mice are the model subject... +
Research Partners
Hasna – PLEX RP
Cecilia – PLEX RP
Renaud – PLEX RP
Isabelle – PI
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Meeting 03 Episode 01 – What do we mean by “trauma”? – A second look…
What do we mean when we talk about “trauma”? Isabelle and her PLEX-RPs take another shot at defining the phenomenon at the heart of her research - without which, a deeper understanding of the scientific and clinical ramifications are difficult +
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Meeting 03 Episode 02 – How do we deal with the mental fallout of trauma?
What happens once you realise you have suffered severe childhood trauma? Cecilia reveals a bilateral approach to being bipolar... +
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Meeting 03 Episode 03 – The need to network – collaboration between professionals
Psychiatrists vs Psychologists - Cecilia and Hasna discuss the importance of having these two professions work in close collaboration when seeking a balanced approach to treating PLEX +
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Meeting 03 Episode 04 – How did they memory of trauma resurface?
What happens when something hitherto forgotten comes back and unleashes emotional and psychological chaos? Cecilia begins to unravel the source of her issues and comes to a conclusion that couples courage with resolution... +
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Meeting 03 Episode 05 – On being labelled as “sick”
You want to know how being labelled as "mentally ill” can in and of itself destroy a life? Listen to Renaud as he so eloquently elucidates the semantic pitfalls and complex layers of guilt, stigma and hopelessness associated with coming +
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Meeting 03 Episode 06 – Ideas for future collaboration…
Now that the Zurich SYNERGIES programme has attained cruising speed, Isabelle and the PLEX-RPs start to explore the possibility of other types of collaboration with a view to future publication... +
Research Partners
Hasna – PLEX RP
Cecilia – PLEX RP
Renaud – PLEX RP
Isabelle – PI
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Meeting 04 Episode 01 – Is research funding founded on fads?
Funding for research is a tough nut to crack, especially when you are up against projects which appeal to established parameters or have "preordained" high-profile objectives. Isabelle laments the paucity of financing available to 'lean, mean and provocative" projects that +
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Meeting 04 Episode 02 – Research – A woman’s perspective…
When asked about how a career in science is affected by gender, Isabelle Mansuy relates a number of anecdotes that illustrate the prejudices still affecting women's education... +
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Meeting 04 Episode 03 – “GRAAP – (Associative and psychiatric Action Group) – an institution of interested individuals…”
GRAAP (Associative and psychiatric Action Group) - an institution of interested individuals -Isabelle is curious about the organisation behind her PLEX Research Partners and the group obliges with a detailed expose... +
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Meeting 04 Episode 04 – Laurence and the AFAAP – Fribourg based psychiatric support group
Laurence talks about her involvement with the support group for PLEX based in Fribourg +
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Meeting 04 Episode 05 – Is epigenetic change reversible?
Laurence talks about her involvement with the support group for PLEX based in Fribourg +
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Meeting 04 Episode 06 – Living with mental illness is a full-time job…
Isabelle listens carefully as the PLEX-RPs build a picture of mental illness that steals your existence and is all consuming... +
Research Partners
Hasna – PLEX RP
Cecilia – PLEX RP
Renaud – PLEX RP
Isabelle – PI
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COVID CONFABS – E01
Isabelle Mansuy shares her own "lockdown routine" during the first month of the COVID-19 pandemic... +
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COVID CONFABS – E02
Jacqueline looks back 10 years and compares the current pandemic with her mental state then +
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COVID CONFABS – E03
Isabelle explains how being in lockdown led her team to a new scientific discovery... +
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COVID CONFABS – E04
Isabelle introduces the “Early Cause” consortium while experiments carried out during lockdown find a link between cardiovascular disease and trans-generational trauma... +
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COVID CONFABS – E05
When things go wrong in childhood, it isn’t just the child who suffers. Isabelle offers some hope and scientific evidence of how this deeply disturbing reality might be avoided... +
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COVID CONFABS – E06
How does childhood trauma launch us towards psychiatric issues later in life? Laurence alludes to her own experience and fingers “hypersensitivity” as the culprit... +
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Meeting 05 Episode 01 – Decompensation: what exactly does it mean?
PI Isabelle Mansuy takes a swipe at the meaning of 'decompensation' and, much to the hilarity of the PLEX, misses by a mile… +
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Meeting 05 Episode 02 – What happens during decompensation?
Laurence goes into detail about how she experiences decompensation showing that, even within the reductive terminology of psychological diagnosis, the individual's experience is of utmost importance and essential to gaining insight into the full problematic of mental illness. +
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Meeting 05 Episode 03 – What can trigger decompensation?
Continuing on the theme of decompensation, Isabelle Mansuy asks about the factors that can provoke this kind of response and Cecilia is more than willing to go into the details of how it functions for her… +
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Meeting 05 Episode 04 – Does decompensation have an upside?
When Isabelle asks about decompensation and any possible positive impact it might have for the PLEX-RPs, the discussion rapidly revisits the age old questions of fear and stigma that plague everyone dealing with the 'invisible disability'... +
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Meeting 05 Episode 05 – Are there any warning signs of an imminent decompensation?
Continuing the discussion around decompensation, our PI Isabelle Mansuy asks the $60,000 question: "Is there anyway to know if and when you are about to suffer a relapse?" +
Research Partners
Hasna – PLEX RP
Cecilia – PLEX RP
Renaud – PLEX RP
Isabelle – PI
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